The rhythm that unites: an empirical investigation into synchrony, ritual, and hierarchy

Synchrony, or rhythmic bodily unison activities such as drumming or cadence marching, has attracted growing scholarly interest. Among laboratory subjects, synchrony elicits prosocial responses, including altruism and empathy. In light of such findings, researchers in social psychology and the bio-cultural study of religion have suggested that synchrony played a role in humanity’s evolutionary history by engendering collectivistic commitments and social cohesion. These models propose that synchrony enhances cohesion by making people feel united. However, such models overlook the importance of differentiated social relations, such as hierarchies. This dissertation builds on this insight by drawing on neuroscience, coordination dynamics, social psychology, anthropology, and ritual studies to generate a complex model of synchrony, ritual, and social hierarchy, which is then tested in an experimental study. In the hypothesized model, shared motor unison suppresses the brain’s ability to distinguish cognitively between self-caused and exogenous motor acts, resulting in subjective self-other overlap. During synchrony each participant is dynamically entrained to a group mean rhythm; this “immanent authority” prevents any one participant from unilaterally dictating the rhythm, flattening relative hierarchy. As a ritualized behavior, synchrony therefore paradigmatically evokes shared ideals of equality and unity. However, when lab participants were assigned to either a synchrony or asynchrony manipulation and given a collaborative task requiring complex coordination, synchrony predicted a marginally lower degree of collaboration and significantly lower interpersonal satisfaction. These findings imply that unity and equality can undercut group cohesion if the collective agenda is a shared goal that requires interpersonal coordination. My results emphasize that, despite the inevitable tensions associated with social hierarchy, complementary roles and hierarchy are vital for certain aspects of social cohesion. Ritual and convention institute social boundaries that can be adroitly negotiated, even as egalitarian effervescence such as communitas (in the sense of Victor Turner) facilitates social unity and inspires affective commitments. These findings corroborate theories in ritual studies and sociology that caution both against excessive emphasis on inner emotive states (such as empathy) and against excessively rigid conventions or roles. An organic balance between unity and functional differentiation is vital for genuinely robust, long-term social cohesion.2018-06-21T00:00:00

Influenza A virus infection and innate immunity in an established murine alveolar-like macrophage model

Influenza is both a seasonal and occasional pandemic respiratory infection in humans, with the most vulnerable of society at the highest risk. With vaccine efficiency dropping and resistance against treatments, better understanding of the host-viral interactions is required to find novel therapy targets. Much of the current understanding for the host-viral interactions comes from epithelial cells or imperfect macrophage models. Alveolar macrophages (AMs) are crucial in the first stages of infection, but due to limited availability, true functional experiments have been impossible. By using the novel AM-like macrophage, Max Plank Institute (MPI) cells, which are available in practically unlimited numbers, this research hopes to expand the current understanding with in-depth functional assays on IAV-macrophage entry mechanisms, immune sensing and signalling, and the resulting effector molecules such as cytokines, chemokines and type I IFNs. MPI macrophages are susceptible to IAV infection but this results abortive replication, following established understandings. However, MPI macrophages are much more sensitive to influenza infection than non-AM models, resulting in a greater pro-inflammatory cytokine, chemokine, and type I IFN responses. This sensitivity 8 highlighted the differences between both strains and individual isolates, with specific binding, infectivity and resulting immune responses all highly variable in different cell types. The effective cleavage of the viral hemagglutinin was key to successful infection, with TPCK-treated trypsin in cell culture much less efficient than the egg counterpart. Influenza propagation techniques that result in this less efficient cleavage limit the impact of downstream functional immune assays. In MPI macrophages reduced pro-inflammatory cytokines and type-I IFN production was observed as a result of this difference in cleavage, however chemokine remained primarily unaffected. The entry mechanisms of IAV in macrophages are much more complex than their epithelial counterparts. While in both cell types sialic acid is the primary attachment receptor for the viruses, in macrophages co-receptor binding by a variety of receptors is utilised to internalise influenza efficiently. Receptors such as the C-type lectins MMR and MGL are utilised to different extents in different macrophage models. However, in MPI macrophages the scavenger receptor MARCO seems to be the main co-receptor, involved in viral uptake but not in direct viral binding to the cell surface. Viral uptake in MPI cells showed that both macropinocytosis and clathrin mediated endocytosis are required for optimal infection, unlike epithelial counterparts where the two mechanisms work in a redundancy partnership. Following from this the current model of IAV endosome escape is the same in MPI macrophages as epithelial cells. With endosomal acidification facilitating HA fusion to the endosome to allow viral RNP escape. Upon detection of IAV by the macrophage three distinct immune response phases occur, two ‘early’ before RNA replication and one ‘late’ after replication. These phases 9 line up with the binding, endosomal, and RNA replication phases of the viral infection cycle, resulting in the production of key effector molecules at each point. These two ‘early’ responses occur independently of viral RNA replication resulting in MAPK and NF-κB activation. The resulting pro inflammatory cytokines produced from these early responses aid the early influx of innate and adaptive immune cells to the infection site. On the other hand, the ‘late’ response is dependent on viral RNA replication, utilising TBK-1 and IRF-3 signalling to induce an antiviral state and viral killing. This late response also seems to play a role in resolving the ‘early’ responses to prevent the cytokine storm associated with severe uncontrolled response. The complexity and varied response to influenza in MPI macrophages, show the benefits of using relevant cell models, which are available in sufficient numbers for functional immune studies. Understanding influenza and AM interactions is paramount for future therapies against a disease with rising health burdens.Public Health England (PHE

APPROACH BY GREAT WHITE SHARK ELICITS FLIGHT RESPONSE IN BOTTLENOSE DOLPHINS

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75252/1/j.1748-7692.1996.tb00074.x.pd

The role of fine sediment characteristics and body size on the vertical movement of a freshwater amphipod

1. Sedimentation and clogging (colmation) of interstitial pore spaces with fine sediment particles is widely considered to be one of the most significant threats to lotic ecosystem functioning. This paper presents the results of a running water mesocosm study examining the effect of benthic and hyporheic fine sediment loading and particle size on the vertical movement and distribution of the freshwater amphipod Gammarus pulex. 2. A gradient of fine sediment loading and different particle sizes were used to examine the ability of G. pulex from two body size classes to access and migrate vertically within subsurface sediments. 3. We tested three hypotheses: i) sediment loading would modify the distribution of G. pulex by limiting vertical movement; ii) the deposition of large particles and heterogenous sediments would limit the vertical movement of individuals more than homogeneous fine grained sediments; and iii) large bodied individuals would be prevented from migrating vertically with increasing sediment loading and particle size / heterogeneity. 4. Sediment loading, particle size and heterogeneity of deposited sediment had a significant effect on the vertical movement of individuals, with heterogeneous sand (0.125 - 4 mm) acting as the strongest barrier to the vertical movement of individuals through the infilling and clogging of interstitial spaces followed by coarse (1 - 4mm) and fine sand (0.125 - 4 mm). 5. Fine sediment loading and particle size acted as a filter on body size and limited the ability of large bodied individuals to migrate vertically to a greater extent than small bodied individuals. 6. This study demonstrates that the effects of fine sediment on habitat availability and faunal movement is dependent on both sedimentological characteristics and an individual’s body size. The results illustrate the importance of both abiotic and biotic factors when evaluating the ecological 66 effects of fine sediment deposition

Evolving social dynamics prime thermal tolerance during a poleward range shift

Peer reviewedPostprin

Resolution of Clinical Signs of Ventilator-Associated Pneumonia in Trauma Patients

Objectives: The ATS/IDSA Ventilator-Associated Pneumonia (VAP) guidelines suggest that clinical improvement of VAP should be apparent within 3–6 days. This study evaluated resolution of clinical signs of VAP in trauma patients after diagnosis. Methods: Critically injured adults admitted to the trauma intensive care unit (ICU) from June 1, 2006, to December 31, 2007, and subsequently given a diagnosis of VAP were retrospectively assessed. Clinical signs, including derangements of maximum temperature (Tmax), white blood cell (WBC) count, and PaO2/FiO2, were evaluated on days 1–16 after VAP diagnosis. Data are presented as mean ± SD unless otherwise stated. Clinical parameters after VAP were compared using repeated-measures ANOVA with the Tukey test for multiple comparisons. Results: A total of 82 patients were identified. Data for the 34 patients without concurrent infections are presented. Demographic data include: Age 46 ± 17 years; 71% men; 94% blunt trauma; median (IQR) Injury Severity Score 29.5 (24–38); duration of mechanical ventilation 33 ± 27 days; ICU length of stay (LOS) 39 ± 25 days; hospital LOS 53 ± 33 days. Clinical signs following VAP diagnosis: Tmax (°F): Day 1=101.8 ± 1.3, Day 3=101.1 ± 1.1, Day 6=101.1 ± 1.4, Day 16=100.1 ± 3. Compared to Day 1, there was a significant reduction in Tmax at days 10, 11, 12, 13, 14, and 16 (p\u3c0.05 for all). WBC count (cells per microliter): day 1 = 12.9 ± 5, day 3 = 13.7 ± 5, day 6 = 14.4 ± 5, and day 16 = 13.8 ± 6. There was no significant difference in WBC on days 1–16 (p=0.42). PaO2/FiO2: day 1 = 232 ± 108, day 3 = 200 ± 87, day 6 = 218 ± 104, day 16 = 246 ± 126. Differences in PaO2/FiO2 on days 1–16 did not reach statistical significance (p=0.06). Conclusion: Improvement of clinical parameters after a VAP diagnosis is delayed in trauma patients. Alternative methods for determining resolution should be investigated. Published in To be published in Critical Care Medicine’s December 2009 supplement

Comparison of National Policy Frameworks for Marine Renewable Energy within the United Kingdom and France

A report prepared as part of the MERiFIC Project “Marine Energy in FAR Peripheral and Island Communities”The MERiFIC Project: MERiFIC is an EU project linking Cornwall and Finistère through the ERDF INTERREG IVa France (Manche) England programme. The project seeks to advance the adoption of marine energy in Cornwall and Finistère, with particular focus on the island communities of the Parc naturel marin d’Iroise and the Isles of Scilly. Project partners include Cornwall Council, University of Exeter, University of Plymouth and Cornwall Marine Network from the UK, and Conseil général du Finistère, Pôle Mer Bretagne, Technôpole Brest-Iroise, Parc naturel marin d’Iroise, IFREMER and Bretagne Développement Innovation from France. MERiFIC was launched on 13th September at the National Maritime Museum Cornwall and runs until June 2014. During this time, the partners aim to Develop and share a common understanding of existing marine energy resource assessment techniques and terminology; Identify significant marine energy resource ‘hot spots’ across the common area, focussing on the island communities of the Isles of Scilly and Parc Naturel Marin d’Iroise; Define infrastructure issues and requirements for the deployment of marine energy technologies between island and mainland communities; Identify, share and implement best practice policies to encourage and support the deployment of marine renewables; Identify best practice case studies and opportunities for businesses across the two regions to participate in supply chains for the marine energy sector; Share best practices and trial new methods of stakeholder engagement, in order to secure wider understanding and acceptance of the marine renewables agenda; Develop and deliver a range of case studies, tool kits and resources that will assist other regions. To facilitate this, the project is broken down into a series of work packages: WP1: Project Preparation; WP2: Project Management; WP3: Technology Support; WP4: Policy Issues; WP5: Sustainable Economic Development; WP6: Stakeholder Engagement; WP7: Communication and DisseminationThis report provides a comparative assessment of the wider planning, innovation and energy policy instruments relevant to marine renewable energy and applicable to the regions of Brittany in France and South West England. In addition to this, aspects of the wider institutional and political contexts in each country that have an adverse or positive effect upon policies for marine renewable energy (such as regionalisation, devolution or European legislation) are covered when considered appropriate and of value. The intention of this document is to highlight best-practice policies and highlight opportunities and examples of where these have been put into place both nationally and regionally within the two study areas. This work will then feed on to later MERiFIC documents, (specifically within work packages 5 and 6, concerning Sustainable Economic Development and Stakeholder Engagement respectively). The primary reference sources for this document are the two earlier MERiFIC report: National Policy Framework for Marine Renewable Energy within the United Kingdom and National Policy Framework for Marine Renewable Energy within France (Vantoch-Wood et al., 2012, Kablan et al., 2012)

National Policy Framework for Marine Renewable Energy within the United Kingdom

A report prepared as part of the MERiFIC Project "Marine Energy in Far Peripheral and Island Communities"The MERiFIC Project: MERiFIC is an EU project linking Cornwall and Finistère through the ERDF INTERREG IVa France (Manche) England programme. The project seeks to advance the adoption of marine energy in Cornwall and Finistère, with particular focus on the island communities of the Parc naturel marin d’Iroise and the Isles of Scilly. Project partners include Cornwall Council, University of Exeter, University of Plymouth and Cornwall Marine Network from the UK, and Conseil général du Finistère, Pôle Mer Bretagne, Technôpole Brest-Iroise, Parc naturel marin d’Iroise, IFREMER and Bretagne Développement Innovation from France. MERiFIC was launched on 13th September at the National Maritime Museum Cornwall and runs until June 2014. During this time, the partners aim to Develop and share a common understanding of existing marine energy resource assessment techniques and terminology; Identify significant marine energy resource ‘hot spots’ across the common area, focussing on the island communities of the Isles of Scilly and Parc Naturel Marin d’Iroise; Define infrastructure issues and requirements for the deployment of marine energy technologies between island and mainland communities; Identify, share and implement best practice policies to encourage and support the deployment of marine renewables; Identify best practice case studies and opportunities for businesses across the two regions to participate in supply chains for the marine energy sector; Share best practices and trial new methods of stakeholder engagement, in order to secure wider understanding and acceptance of the marine renewables agenda; Develop and deliver a range of case studies, tool kits and resources that will assist other regions. To facilitate this, the project is broken down into a series of work packages: WP1: Project Preparation; WP2: Project Management; WP3: Technology Support; WP4: Policy Issues; WP5: Sustainable Economic Development; WP6: Stakeholder Engagement; WP7: Communication and DisseminationThis document is intended to provide an introduction into the international, national and regional policy and legislation framework relevant to the deployment of marine renewable energy technologies within the UK, and specifically with a focus upon the South West and the county of Cornwall and its neighbouring Isles of Scilly. Within the context and scope of this document, devices that utilize wave, tidal stream, and floating wind within the marine environment are included within the definition of ‘marine renewable energy devices’ however limited focus is also given to offshore fixed wind turbines as it is recognised that, (although outside of the scope and context of this document and at a much further stage of technology maturity) there are many complimentarities between these technology groupings